KMID : 0043320100330121927
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Archives of Pharmacal Research 2010 Volume.33 No. 12 p.1927 ~ p.1932
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A new triterpene and an antiarrhythmic liriodendrin from Pittosporum brevicalyx
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Feng Chun
Li Bo Gang Gao Xiao Ping Qi Hua Yi Zhang Guo Lin
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Abstract
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A new triterpene, 21-O-senecioyl-R1-barrigenol (1) and 13 known compounds were isolated from the ethanol extracts of the leaves and bark of Pittosporum brevicalyx (Oliv.) Gagnep. Their structures were elucidated based on spectral data. The antiarrhythmic action of one furofuran lignan, liriodendrin (2), was tested on a model of CaCl2-induced arrhythmia and compared with the effect of verapamil. The prophylactic administration of liriodendrin (2) was effective in prolonging latency of arrhythmia and reducing the occurrence of ventricular fibrillation from 75% to 25%. The overall mortality rate was significantly reduced by the prophylactic administration of liriodendrin from 87.5% to 25%. The antiarrhythmic effect of liriodendrin (5.0 mg/kg) was similar to that of verapamil (1.05 mg/kg). Thus, liriodendrin may be a potent suppressor of CaCl2-induced arrhythmias.
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KEYWORD
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Pittosporum brevicalyx, Liriodendrin, Antiarrhythmic, CaCl2-induced arrhythmias
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